痛经宁颗粒治疗原发性痛经的临床观察

目的探讨中药痛经宁颗粒治疗原发性痛经(PD)的作用机制。方法以痛经宁颗粒治疗PD患者120例，并设西药阿司匹林治疗的40例作对照，同时对部分患者进行了治疗前后黄体中、末期血清雌激素(E2)、孕激素(P)，黄体中期、经期内皮素(ET)和降钙素基因相关肽(CGRP)含量的检测。结果治疗组临床疗效优于对照组(P<0．01)；对重度、中度PD患者的显愈率及主要兼症的改善率优于对照组(P<0．01)。治疗后治疗组E'水平、ET含量较治疗前明显下降(P<0．01)；P、CGRP含量则明显上升(P<0．01)。结论中药痛经宁颗粒可调节雌孕激素、ET和CGRP；并具有调整精神、情绪，促进机体内环境平衡及疗效巩固的优势。

Effect of Tongjingning Granule on Primary Dysmenorrhea

OBJECTIVE: To study the mechanisms of tongjingning granule (TJN) on primary dysmenorrhea (PD). METHODS: One hundred and twenty PD patients were treated with TJN, and 40 patients treated with aspirin as controls. The levels of serum estrogen (E2) and progestin (P) content in the luteal metaphase and anaphase (MI/AI) as well as endothelin (ET) and calcitonin gene related peptide (CGRP) in the metaphase and menstrual stage before and after treatment in partial patients were determined. RESULTS: The therapeutic effect , and the curative markedly-effective rate and improvement rate of main accompanied symptoms of severe and moderate PD patients in the treated group were superior than those in the control group (P < 0.01). The level of E2 and ET were significantly decreased, and the content of P and CGRP were significantly increased in the treated group after treatment respectively (P < 0.01). CONCLUSION: JTN not only can regulate ovarian hormone, ET and CGRP, but shows advantages in adjusting spirits and emotions, improving homeostasis and consolidating the therapeutic effect.