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Clockwise hysteresis or proteresis
Authors:Pascal Girard  Jean-Pierre Boissel
Institution:(1) Unité de Pharmacologie Clinique, Hôpital Neuro-Cardiologique, 162 Avenue Lacassagne, 69424 Lyon Cedex 03, France
Abstract:The authors propose the word ldquoproteresisrdquo to designate the clockwise hysteresis, i.e., when an effect increases more rapidly than the observed drug concentrations. Such a phenomenon has been recently described for aspirin and nicotine. Indeed hysteresis means ldquowhich comes after,rdquo while ldquoproteresis,rdquo the greek symmetrical word, means ldquowhich comes earlier,rdquo a more appropriate term for the described situation.
Keywords:hysteresis  proteresis  pharmacodynamic modeling
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