Clockwise hysteresis or proteresis |
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Authors: | Pascal Girard Jean-Pierre Boissel |
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Institution: | (1) Unité de Pharmacologie Clinique, Hôpital Neuro-Cardiologique, 162 Avenue Lacassagne, 69424 Lyon Cedex 03, France |
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Abstract: | The authors propose the word proteresis to designate the clockwise hysteresis, i.e., when an effect increases more rapidly than the observed drug concentrations. Such a phenomenon has been recently described for aspirin and nicotine. Indeed hysteresis means which comes after, while proteresis, the greek symmetrical word, means which comes earlier, a more appropriate term for the described situation. |
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Keywords: | hysteresis proteresis pharmacodynamic modeling |
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