DIFFERENTIAL DIAGNOSIS BETWEEN HYPOTHALAMIC AND PITUITARY hGH DEFICIENCY WITH THE AID OF SYNTHETIC GH-RH 1–44 |
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| Authors: | Z LARON R KERET B BAUMAN A PERTZELAN Z BEN-ZEEV D B OLSEN A M COMARU-SCHALLY A V SCHALLY |
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| Institution: | Institute of Pediatric and Adolescent Endocrinology and Dept. of Pharmacy, Beilinson Medical Center and Sackler School of Medicine, Tel Aviv University, Israel and Endocrine and Polypeptide Laboratory, Veterans Administration Center and Tulane University School of Medicine, New Orleans, Louisiana, USA |
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| Abstract: | Synthetic GH-RH 1–44 administered as an intravenous bolus (1 μg/kg) evoked a marked hGH rise (>20 ng/ml) in three children with constitutional short stature and in two of eight children diagnosed as having hGH deficiency by insulin hypoglycaemia and/or clonidine tests. As judged by the intensity of the hGH response to the dose employed and the peak time, GH-RH 1–44 may be as potent as GH-RH 1–40 in children. It is concluded that GH-RH is an important addition to the endocrine armamentarium, providing the means for differentiation between hypothalamic and pituiary hGH deficiency in a simple test which is devoid of side effects. |
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