水通道蛋白1与内皮细胞功能

 水通道蛋白1（AQP1）是目前唯一发现在内皮有表达的水通道蛋白，在肾脏尿浓缩机制、小肠吸收乳糜微粒和角膜内皮的液体平衡中有重要作用；在血管内皮细胞中促进NO和CO2转运，调节血管舒缩功能，与心肌缺血后水肿和坏死关系密切，促进内皮细胞迁移，影响血管形成和肿瘤播散。

Aquaporin-1 and endothelial function

Aquaporin-1 (AQP1), the only water channel that expressed in most microvascular endothelia outside of brain, plays an important role in the mechanism of urinary concentration in outer modularly descending vasa recta, in chylomicron absorption in lacteal endothelia, and in fluid balance across the corneal endothelium. In vascular endothelium, AQP1 is closely related to nitric oxide (NO) and CO2 transport, vascular function of dilatation and contraction, myocardial edema and necrosis after myocardial ischemia, angiopoiesis, migration of endothelial cells and tumor spread.