Plasma ionized magnesium in tubular disorders with and without total hypomagnesemia |
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Authors: | I D Morger A C Truttmann R O von Vigier A Bettinelli G P Ramelli M G Bianchetti |
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Institution: | (1) Division of Nephrology, Departments of Pediatrics, CH-3010 Bern, Switzerland e-mail: mbianche@insel.ch, Tel.: +41-31-6329479; Fax: +41-31-6329444, CH |
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Abstract: | Selective electrodes have been designed for determining plasma ionized magnesium. In kidney disease the relationship between
ionized and total circulating magnesium is often altered. Hence plasma ionized magnesium (ETH 7025 membrane) was determined
in 25 patients with primary renal tubular disorders; 6 patients had total hypomagnesemia. Total plasma magnesium was never
reduced in the remaining 19 patients. Plasma ionized magnesium values were low in the 6 patients with total hypomagnesemia.
In 18 of the 19 patients without total hypomagnesemia plasma ionized magnesium values were not reduced. Ionized hypomagnesemia
was noted in a patient with normal total plasma magnesium in the context of hypercalciuric nephrocalcinosis of unknown origin.
The study demonstrates an excellent concordance between plasma total and ionized magnesium in tubular disorders associated
with total hypomagnesemia and a good concordance in tubular disorders that are not linked with total hypomagnesemia. The determination
of circulating ionized magnesium is of little value in the diagnostic work-up of the vast majority of renal tubular disorders.
The determination might perhaps disclose latent hypomagnesemia in nephrocalcinosis of unknown cause.
Received: 20 March 1998 / Revised: 28 May 1998 / Accepted: 29 May 1998 |
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Keywords: | Hypocalcemia Magnesium deficiency Ionized magnesium Renal tubular transport Inborn errors |
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