Research on the molecular basis of neoplasms: malignant melanoma as an example |
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Authors: | D Birnbaum J Adelaide I Marics F Raybaud |
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Institution: | Unité 119 INSERM, Marseille, France. |
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Abstract: | Knowledge about genetic alterations occurring in human tumors has dramatically increased following the development of cytogenetic and molecular techniques. Various alterations have been characterized: chromosomal damages, oncogene activations, loss of genetic material. Some of those alterations, such as c-abl rearrangements in certain leukemias, are characteristic of a certain type of malignancy. However, in most tumors, no such correlation has been demonstrated. We review here the genetic alterations discovered in human malignant melanomas. |
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