High synovial immunoglobulin E levels in eosinophilic synovitis. |
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| Authors: | S Padeh R M Laxer G J Gleich P F Armstrong E D Silverman |
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| Affiliation: | Department of Pediatrics and Surgery, Hospital for Sick Children, Toronto, Ontario, Canada. |
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| Abstract: | Eosinophilic synovitis occurred in a 7-year-old boy. Synovial fluid leukocytes were mostly eosinophils; the peripheral blood showed only mild eosinophilia. The level of eosinophil-derived neurotoxin in the synovial fluid was higher than that in the serum, suggesting intraarticular eosinophil degranulation. The IgE level was also elevated in the synovial fluid (3854 ng/ml) but normal in the serum (408 ng/ml), suggesting a localized immediate hypersensitivity immune response. |
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