脑出血大鼠肠黏膜组织形态学变化与血浆儿茶酚胺水平的关系

目的探讨脑出血大鼠肠黏膜组织形态学变化与血浆儿茶酚胺(肾上腺素、去甲肾上腺素)水平之间的关系。方法制作脑出血大鼠模型,检测正常组、假手术组及脑出血后24h、48h、72h(每组8只)肠黏膜组织形态学参数及血浆肾上腺素、去甲肾上腺素水平。进行空肠黏膜组织形态学参数值与血浆肾上腺素、去甲肾上腺素水平之间的相关分析。结果小肠绒毛高度与血浆肾上腺素(r=-0.566,P<0.01)、血浆去甲肾上腺素(r=-0.545,P<0.01);绒毛面积与血浆肾上腺素(r=-0.755,P<0.01)、血浆去甲肾上腺素(r=-0.702,P<0.01);黏膜厚度与血浆肾上腺素(r=-0.478,P<0.01)、血浆去甲肾上腺素(r=-0.405,P<0.01);肠壁厚度与与血浆肾上腺素(r=-0.536,P<0.01)、血浆去甲肾上腺素肠(r=-0.489,P<0.01)均成显著的负相关。结论脑出血时肠黏膜组织形态学变化与血浆儿茶酚胺水平呈负相关。

Correlation between intestinal mucosa tissue morphologic parameters and plasma catecholamines level in rats with cerebral hemorrhage

Objective To explore the correlation between intestinal mucosa tissue morphologic changes and plasma catecholamines(adrenaline and norepinephrine) level in rats with cerebral hemorrhage.Methods A rat model of hemorrhage was used to detect the intestinal mucosa tissue morphologic parameters changes and the plasma catecholamines(adrenaline and norepinephrine) level at 24h,48h and 72h after the hemorrhage.The results were compared to normal control group and the sham-operated group.The correlation between the jejunal mucosa tissue morphologic parameters changes and plasma adrenaline and plasma norepinephrine were also explored.Results Small intestinal villous height was negatively correlated with the level of plasma adrenaline(r=-0.566,P<0.01) and plasma norepinephrine(r=-0.545,P<0.01).Small intestinal villous area was negatively correlated with the level of plasma adrenaline(r=-0.755,P<0.01) and plasma norepinephrine(r=-0.702,P<0.01).Mucosal thickness was negatively correlated with the level of plasma adrenaline(r=-0.478,P<0.01) and plasma norepinephrine(r=-0.405,P<0.01).Bowel wall thickness was negetively correlated with the level of plasma adrenaline(r=-0.536,P<0.01) and plasma norepinephrine(r=-0.489,P<0.01).Conclusion Small intestinal mucosa tissue morphologic parameters changes were negatively correlated with the level of plasma catecholamines in rats with cerebral hemorrhege.