| 黄酮碳苷化合物抗炎活性的QSAR初步探讨 |
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| 引用本文： | 吴新安,秦峰,都模琴.黄酮碳苷化合物抗炎活性的QSAR初步探讨[J].时珍国医国药,2012,23(3):632-633. |
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| 作者姓名： | 吴新安 秦峰 都模琴 |
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| 作者单位： | 中国人民解放军105医院,安徽合肥,230031 |
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| 基金项目： | ,中国人民解放军南京军区"122"工程培养项目,中国人民解放军南京军区"十一·五"基金项目,安徽省卫生厅临床科研项目 |
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| 摘 要： | 目的探讨黄酮碳苷类化合物抗炎活性的构效关系。方法从短瓣金莲花中分离制备12个黄酮碳苷系列化合物,进行抗炎活性评价。结果黄酮碳苷化合物的糖基、酚羟基的取代位置、数量等影响黄酮碳苷的抗炎活性。结论黄酮碳苷类化合物的抗炎活性具有一定的构效关系。
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| 关 键 词： | 黄酮碳苷类化合物 构效关系 抗炎活性 |
The QSAR Study on Anti - inflammatory Activities of C - glycosyflavones |
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| WU Xin-an
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QING Feng
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DU Mo-qin.The QSAR Study on Anti - inflammatory Activities of C - glycosyflavones[J].Lishizhen Medicine and Materia Medica Research,2012,23(3):632-633. |
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| Authors: | WU Xin-an QING Feng DU Mo-qin |
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| Institution: | (No.105th Hospital of PLA,Hefei,Anhui,230001,P.R.China) |
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| Abstract: | Objective To study the QSAR of C-glycosyflavones on anti-inflammatory activities. Methods 12 C-glycosyflavones were prepared from the extract of Trollius ledebouri Reichb and their anti-inflammatory activities were evaluated by TPA-induced mouse ear edema(in vivo). Results The main factors were sugar moiety and OH affecting the anti-inflammatory activities of C-glycosyflavones. Conclusion The QSAR of C-glycosyflavones were identified. |
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| Keywords: | C-glycosyflavones Quantitative structure-activity relationship Anti-inflammatory activity |
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