川崎病患儿并发冠状动脉损伤的危险因素

目的基于川崎病(Kawasaki disease,KD)患儿静脉注射免疫球蛋白(intravenous immunoglobulin,IVIG)初始治疗前的生物学指标检测,分析KD患儿并发冠状动脉损伤(coronary artery lesions,CAL)的危险因素。方法回顾性分析43例KD并发CAL(CAL组)患儿和70例KD未并发CAL(NCAL组)患儿的临床资料,进行单因素分析(χ2检验);对单因素分析结果提示与CAL发生率有显著相关的因素,进行多元Logistic逐步回归分析。结果男性、年龄≤1岁、白细胞计数(WBC)>12×109/L、血清白蛋白(ALB)<35g/L、中性粒细胞百分比>80%、超敏C反应蛋白(CRP)≥100mg/L是KD患儿并发CAL的危险因素,其OR值分别为1.69、4.02、3.06、2.42、2.92、4.05。结论存在男性、年龄≤1岁、WBC>12×109/L、ALB<35g/L、中性粒细胞百分比>80%、CRP≥100mg/L这些高危因素的KD患儿并发CAL可能性大,需要更强化的治疗,更密切的随访。

Risk Factors of Coronary Artery Lesions in Kawasaki Disease Children

Objective To investigate the risk factors of coronary artery lesions(CAL)in Kawasaki disease(KD)children,based on the testing results of the biomarkers before the initial treatment of intravenous immunoglobulin(IVIG).Methods The clinical data of 43 cases of KD with CAL(CAL group)and 70 cases of KD with no-CAL(NCAL group)were retrospectively analyzed by using the single factor analysis(χ2 tests).A multivariable logistic regression analysis was conducted to identify significiantly related factors with the incidence of CAL by the single factor analysis.Results Male,age ≤ 1-year-old,white blood cell count(WBC)>12×109/L,albumin(ALB)<35 g/L,neutrophil(%)>80%,and C-reactive protein(CRP)≥ 100 mg/L were the risk factors of CAL secondary to KD,and the OR values were 1.69,4.02,3.06,2.42,2.92 and 4.05 respectively.Conclusion The KD children with the risk factors above had higher incidence of CAL,and needed more intensive treatment and closer follow-up.