| 生物转化在天然甘草药物活性成分中的研究进展 |
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| 引用本文： | 卢定强,孙磊,凌岫泉,卢震寰,高林.生物转化在天然甘草药物活性成分中的研究进展[J].时珍国医国药,2012,23(2):454-456. |
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| 作者姓名： | 卢定强 孙磊 凌岫泉 卢震寰 高林 |
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| 作者单位： | 1. 南京工业大学药学院,江苏 南京 210009;江苏省药物研究所,江苏 南京 210009
2. 南京工业大学药学院,江苏 南京,210009 |
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| 基金项目： | 国家自然科学基金,国家重点基础研究发展计划项目 |
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| 摘 要： | 药用甘草活性成分的生物转化一直是国内外研究的热点。文章从植物细胞培养、微生物和游离酶为生物催化剂角度综述了天然甘草活性成分的生物转化,其反应包括水解、羟基化、糖基化、酰基化等多种类型,并在生物转化体系的筛选、转化条件的优化、转化率的提高及酶的分离纯化方面取得了一些进展。这增加天然产物结构多样性、寻找药物先导化合物、促进珍稀物种资源可持续利用、提高生产效率、降低成本等多个环节均有广泛的应用价值。
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| 关 键 词： | 甘草酸 甘草酸衍生物 差向异构体 生物转化 酶促反应 |
Research Progress in Biotransformation for Biological Active Constituents from Natural Glycyrrhiza Medicines |
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| LU Ding-qiang
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SUN Lei
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LING Xiu-quan
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LU Zhen-huan
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GAO Lin.Research Progress in Biotransformation for Biological Active Constituents from Natural Glycyrrhiza Medicines[J].Lishizhen Medicine and Materia Medica Research,2012,23(2):454-456. |
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| Authors: | LU Ding-qiang SUN Lei LING Xiu-quan LU Zhen-huan GAO Lin |
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| Institution: | 1(1.School of Pharmacology,Nanjing University of Industry,Nanjing 210009,China;2.Jiangsu Provincial Institute of Material Medica,Nanjing 210009,China) |
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| Abstract: | Biotransformation of biological active constituents from natural glycyrrhiza medicines has been researched focus at home and abroad.Based on the plant cell culture,microbial and free enzymes as biological catalysts,this review summaries biotransformation of active constituents from natural glycyrrhiza,which include hydrolysis,hydroxylation,glycosylation,acylation and so on,and make some progress in the screening of biotransformation system,optimization of transformation conditions,an increase of conversion rate and the separation of enzymes.It will have great potential value in increasing structural diversity of natural products,finding lead compounds for drugs,promoting the sustainable use of rare species resources,improving production efficiency and reducing costs in the future. |
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| Keywords: | Glycyrrhizic acid Glycyrrhizic acid derivatives Epimer Biotransformation Enzyme catalysis |
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