螺圈加胶水法封堵兔肺支气管的实验研究

目的评价对于兔支气管最佳的螺圈加胶水封堵组合。方法分别以3mm螺圈 生物蛋白胶(A组)、3mm螺圈 NBCA胶(B组)、2mm螺圈 NBCA胶(C组)及4mm螺圈 NBCA胶(D组)封堵兔两肺前叶支气管,每组共8个部位。分别观察螺圈咳出、移位、肺叶萎陷、炎症程度及螺圈处异物肉芽肿的状况(分别记为0~2分)。结果B组评分明显高于其他组,与A组差异有显著性(P=0.009),与C组、D组差异亦有显著性(P值均为0.015)。结论适当大小的螺圈(直径3mm)可减少咳出、移位率和并发症;此外,NBCA胶比生物蛋白胶能更有效地造成肺萎陷。

Experimental study on coil-and-glue occlusion of bronchi in rabbits

Objective To evaluate the optimal combination of coil and glue used in the bronchial occlusion of rabbits. Methods Three mm coil with albumin gel(A group), 3 mm coil with NBCA(B group), 2 mm coil with NBCA(C group) and 4 mm coil with NBCA(D group) were used respectively to occlude the bilateral anterior bronchi of rabbits. Each group composed of 4 rabbits with 8 anterior bronchi. After the bronchial occlusion of the rabbits, the coil expectoration, lobe collapse, inflammation and foreign-body granuloma formation were observed and scored as 0 to 2. Results There was statistical difference between B group and A group (P=0.009), and was also different in comparing with those of the C and D groups. Conclusions Proper-sized coil(3 mm) may reduce the rates of expectoration and other complications. NBCA is more effective than albumin gel in making lung collapse.