| 秦艽抗甲型流感病毒的药效学实验研究 |
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| 引用本文： | 李福安,李永平,童丽,李文渊,热增才旦,袁冬平.秦艽抗甲型流感病毒的药效学实验研究[J].世界科学技术,2007,9(4):41-45. |
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| 作者姓名： | 李福安 李永平 童丽 李文渊 热增才旦 袁冬平 |
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| 作者单位： | [1]青海大学医学院,西宁810001 [2]南京中医药大学药学院,南京210046 |
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| 基金项目： | 科技部科技攻关项目;青海省科技厅资助项目 |
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| 摘 要： | 目的：研究秦艽抗甲型流感病毒的药理作用。方法：复制甲型流感病毒感染小鼠肺部感染性疾病动物模型，以利巴韦林为阳性对照，观察秦艽对甲型流感病毒感染小鼠的保护作用。结果：秦艽提取物可明显延长甲型流感病毒感染小鼠存活天数和存活率；对甲型流感病毒感染小鼠肺指数、肺组织形态学都有保护作用，与模型组比较具有显著性差异（P〈0．05）。结论：秦艽具有较好的抗甲型流感病毒感染的作用，值得开发利用。
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| 关 键 词： | 秦艽 甲型流感病毒 药效学 中草药 临床疗效 |
| 收稿时间： | 2007-04-23 |
| 修稿时间： | 2007-05-16 |
Pharmacodynamic Effects of Gentiana against Influenze A Virus |
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| Li Fuan,Li Yongping,Tong Li,Li wenyuan,Rezen Caidan,Yuan Dongping.Pharmacodynamic Effects of Gentiana against Influenze A Virus[J].World Science and Technology(Modernization of Traditional Chinese Medicine),2007,9(4):41-45. |
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| Authors: | Li Fuan Li Yongping Tong Li Li wenyuan Rezen Caidan Yuan Dongping |
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| Institution: | 1. Qinghai University Medical College, Qinghai, Xining, 810001 China;2. Nanjing University of Traditional Chinese Medicine, Nanjing, 210046, Jiangsu, China |
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| Abstract: | Authors investigated the pharmacological effects of gentiana against influenza A virus. In the study, the pneumonia mice were infected with influenza A virus. Authors observed that gentiana protected the mice infected with influenza A virus, using ribavirin as a positive reference drug. It is found that gentiana extracts has obviously prolonged both survival days and survival rate of the mice infected with influenza A virus, and it protected their lung index and lung morphology as well. There is a significant difference compared with the model group. It is concluded that Gentiana has a better effect on mice infected with influenza A virus, and it is worth further study. |
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| Keywords: | Gentiana influenza A virus pharmacodynamics traditional Chinese herb/therapy |
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