| 实验性糖尿病兔生长素受体的变化 |
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| 引用本文： | 苏青,马屾. 实验性糖尿病兔生长素受体的变化[J]. 山东大学学报(医学版), 1994, 0(2) |
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| 作者姓名： | 苏青 马屾 |
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| 作者单位： | Dept. of Biochemistry，Shandong Medical University |
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| 摘 要： | 通过观察正常兔、四氧嘧啶糖尿病兔及胰岛素（ＩＮＳ）治疗兔的血糖含量、体重和生长素受体（ＧＨＲ）含量的变化，研究ＩＮＳ、ＧＨＲ及胰岛素样生长因子－Ⅰ（ＩＧＦ－Ⅰ）三者的关系，以探讨ＩＮＳ缺乏所致生长素（ＧＨ）抵抗现象的机理。结果表明，当ＩＮＳ完全缺乏，血糖极度升高时，体重严重丢失，降至原体重的７５％，而ＧＨＲ仅降至正常值的４２％。提示，ＩＮＳ对ＧＨ促生长效应具有双调节作用，既能直接刺激ＧＨＲ生成，又可作用于受体后机制，直接促进ＩＧＦ－Ⅰ生成。
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| 关 键 词： | 糖尿病，胰岛素，生长激素，受体，内源性物质，血糖，体重，嘧啶类，兔 |
CHANGES OF GROWTH HORMONE RECEPTORS IN EXPERIMENTAL DIABETIC RABBITS |
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| Su Qing ,Ma Xin. CHANGES OF GROWTH HORMONE RECEPTORS IN EXPERIMENTAL DIABETIC RABBITS[J]. Journal of Shandong University:Health Sciences, 1994, 0(2) |
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| Authors: | Su Qing Ma Xin |
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| Abstract: | Experimental diabetes in rabbits was induced by alloxan injection and the levels of blood sugar, weight changes and hepatic growth hormone receptors ( GHR ) were measured in normal, diabetic and insulintreated diabetic animals to explore the mechanism of growth hormone resistance.The reults showed that the body weight was severely lost to 75% of origin but the GHR values were reduced to 42% of normal when insulin was deprived of, the level of blood sugar was extremely high.The results propose the dual regulation of growth-Promoting action Of growth hormone by insulin: it stimulates the synthesis of GHR and acts on the mechanism of postreceptor to promote the expression of insulin-like growth factor- I . |
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| Keywords: | Diabetes mellitus Insulin Somatotropin Receptors endogenous Blood glucose Body weight Pyrimidines Rabbits |
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