Chronic paroxysmal hemicrania: From the index patient to the disease |
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Authors: | Ottar Sjaastad MD |
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Institution: | (1) Department of Neurology, St. Olavs Hospital, N-7006 Trondheim, Norway |
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Abstract: | The first patient with chronic paroxysmal hemicrania (CPH), a 41-year-old woman, first seen in 1961, was followed until an
adequate treatment was found, 12 years later. Clinically, attack frequency and duration differed widely from the general pattern
of cluster headache. Ocular variables, such as intraocular pressure and corneal indentation pulse amplitudes, also differed
in our case (clear symptomatic side increment during attacks) and cluster headache. Pupil reactions to directly and indirectly
acting sympathicomimetic drugs were also vastly different in our case and cluster headache: no signs of Horner’s syndrome
in our patient, while cluster headache exhibits a "Horner-like pattern." In cluster headache, there is a relative hypohidrosis
in the forehead on the symptomatic side if body temperature is increased, and a clear hyperhidrosis on direct parasympathomimetic
stimulation. This was not so in our case. Indomethacin was highly effective in our case, while "cluster headache drugs," such
as ergotamine/sumatriptan, were ineffective. Indomethacin was inactive in cluster headache. Accordingly, our case seemed to
differ decisively from cluster headache: CPH had been discovered. |
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