参鹿强骨胶囊对皮质激素致大鼠骨质疏松症的保护作用

目的 研究参鹿强骨胶囊(SLQG)对皮质激素引起的继发性骨质疏松症的防治作用。方法3月龄SD雌性大鼠，每周2次肌肉注射地塞米松1．0mg／100g体重，并口服SLQG3，1．5，0．75g(折算成生药量)／kg，同时设活性维生素D3(αVD3)阳性对照组；连续2个月后测定大鼠全身骨矿总量(BMC)、骨矿密度(BMD)、股骨的生物力学性能、相对密度、灰重、钙含量，血清的钙、磷含量以及碱性磷酸酶(AKP)活性等。结果 (1)SLQG3g／kg组使BMC和BMD分别提高了10．6％和8．9％，1．5g／妇组分别提高了3．9％和5．8％。(2)SLQG 3g／kg组使股骨的最大负荷和结构强度分别增加了13．3％和31．4％，1．5g／kg组分剐增加了6．9％和23．7％。(3)SLQG 3g／kg组使股骨的湿密度、干密度、灰密度和钙密度分剐增加了4．5％，3．6％，6．1％和7．8％，1．5g／kg组分别增加了2．5％，2．7％，4．4％和3．8％。(4)SLQG对血清钙、磷含量以及AKP活性无明显影响。结论 SLQG对皮质激素致大鼠骨质疏松症具有明显的防治作用。

Protective effect of Shenlu Qianggu capsule on secondary osteoporosis induced by dexamethasone in rats

OBJECTIVE To study the protective effect of Shenlu Qianggu capsule(SLQG) on secondary osteoporosis induced by dexamethasone(DXM) in rats. METHOD Female SD rats,3 month aged, were given intramuscularly with 1.0mg/kg DXM twice a week. The treated groups were orally given SLQG 3.0,1.5 or 0.75g/kg/d for 2 months. The whole body BMC and BMD were detected by DEXA. The biodynamics potency, density, ash weight and calcium content of femur were determined by reported menthods. RESULTS (1) The BMC and BMD in SLQG 3g/kg group were increased by 10.6% and 8.9% than that in model group, while in SLQG 1.5g/kg group by 3.9% and 5.8%. (2) The peak load and hardness of femur in SLQG 3g/kg group were enhanced by 13.3% and 31.4%, when in SLQG 1.5g/kg group by 6.9% and 23.7%. (3) The wet density, dry density, ash density and calcium density of femur in SLQG 3g/kg group were increased by 4.5%,3.6%,6.1% and 7.8%, while in SLQG 1.5g/kg group by 2.5%,2.7%,4.4% and 3.8%. (4) The serum content of calcium, phosphorus and AKP activity in treated groups were no significantly different to that in model group. CONCLUSION SLQG can prevent secondary osteoporosis induced by DXM in rats.