Tannic acid is not mutagenic in germ cells but weakly genotoxic in somatic cells of Drosophila melanogaster |
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| Authors: | Cunha, K.S. Campesato, V.R. Reguly, M.L. Gimmler-Luz, M.C. Graf, U. de Andrade, H.H.R. |
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| Affiliation: | 1Laboratório de Mutagênese, Departmento de Genética, Universidade Federal do Rio Grande do Sul Av. Bento Gonçalves 9500, Campus do Vale, Predio 43323, Caixa Postal 15053, 91501–970 Porto Alegre RS, Brazil 2Institute of Toxicology, Swiss Federal Institute of Technology (ETH) and University of Zürich, CH-8603 Schwerzenbach Switzerland |
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| Abstract: | Tannic acid (TA) was tested for genotoxic activity in threedifferent assays (13) in Drosophila melanogaster by feedingof larvae or adult flies. TA did not induce sex-linked recessivelethals (1) nor sex-chromosome loss, mosaicism or non-disjunction(2) in male germ cells. In the wing somatic mutation and recombinationtest (SMART) (3) TA was found to be toxic for larvae of thehigh bioactivation cross and produced a weak positive response.These results suggest that this compound, when administeredorally to larvae or adults of D.melanogaster, is not mutagenicand clastogenic in male germ cells, but weakly genotoxic insomatic cells of the wing imaginal disk. 3To whom correspondence should be addressed |
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