喉鳞状细胞癌与雌激素受体的关系

用酶抗酶免疫复合物（ＰＡＰ）法测定了５０例喉鳞状细胞癌及１０例声带息肉，１例声带乳头瘤样增生的雌激素受体（ＥＲ）和孕激素受体（ＰｇＲ）。结果表明，正常喉组织及声带息肉雌、孕激素受体均为阴性。喉鳞状细胞癌的雌、孕激素受体的阳性率分别为６０％和５６％，其中高分化鳞状细胞癌的雌、孕激素受体阳性率明显高于低分化者（Ｐ＜０．０５）。受体阳性率与临床分期无明显关系（Ｐ＞０．０５）。此结果提示雌激素受体的出现与喉癌细胞的分化程度有关。测定喉鳞状细胞癌的雌激素受体对于喉癌的发生、发展及预后有进一步研究的价值。

Relation of Laryngeal Squamous Cell Carcinoma andEstrogen Receptors

Estrogen receptor(ER) and progesterone receptor(PgR) weremeasured by horseradish peroxidase antihorseradish peroxidase(PAP) method in50 laryngeal squamous cell carcinomas and 10 polypus of the vocal cord.ER andPgR were negative in normal laryngeal tissue and polypus of the vocal cord.Of the laryngeal cell carcinomas, 60% were ER positive and 56% PgR positive.In addition,ER or PgR content was significantly higher in well-differentiated carcinomathan in poor-differentiated ones(P<0.05).There was no correlation between thepositive rate and clinical staging.This assay showed that there was a relationshipbetween the degree of differentiation of the cancer cells with the presence of ER andPgR.