Personalized nanomedicine |
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Authors: | Lammers Twan Rizzo Larissa Y Storm Gert Kiessling Fabian |
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Institution: | Authors' Affiliations: Department of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany; Department of Pharmaceutics, Utrecht University, Utrecht; and Department of Targeted Therapeutics, University of Twente, Enschede, The Netherlands. |
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Abstract: | Personalized medicine aims to individualize chemotherapeutic interventions on the basis of ex vivo and in vivo information on patient- and disease-specific characteristics. By noninvasively visualizing how well image-guided nanomedicines-that is, submicrometer-sized drug delivery systems containing both drugs and imaging agents within a single formulation, and designed to more specifically deliver drug molecules to pathologic sites-accumulate at the target site, patients likely to respond to nanomedicine-based therapeutic interventions may be preselected. In addition, by longitudinally monitoring how well patients respond to nanomedicine-based therapeutic interventions, drug doses and treatment protocols can be individualized and optimized during follow-up. Furthermore, noninvasive imaging information on the accumulation of nanomedicine formulations in potentially endangered healthy tissues may be used to exclude patients from further treatment. Consequently, combining noninvasive imaging with tumor-targeted drug delivery seems to hold significant potential for personalizing nanomedicine-based chemotherapeutic interventions, to achieve delivery of the right drug to the right location in the right patient at the right time. Clin Cancer Res; 18(18); 4889-94. ?2012 AACR. |
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