左西孟旦治疗急性心力衰竭的临床疗效及对血清脑钠肽的影响

目的 观察左西孟旦治疗急性心力衰竭的临床疗效及对血清脑钠肽的影响.方法 76例急性心力衰竭患者随机分为观察组与对照组各38例.两组均给予常规治疗,对照组加用盐酸多巴酚胺注射液治疗,观察组加用左西孟旦注射液治疗,疗程均为7 d.比较两组治疗前后心功能指标、不良反应发生情况和治疗效果.结果 治疗7 d后,两组脑钠肽水平较治疗前降低,每搏输出量和左室射血分数较治疗前升高,且观察组改善更加明显(P均<0.05).两组不良反应发生率比较差异无统计学意义(P>0.05).观察组治疗效果好于对照组(P<0.05).结论 左西孟旦治疗急性心力衰竭效果好,可明显下调血清脑钠肽水平,且不良反应发生率低,值得在临床推广应用.

Clinical efficacy of levosimendan for treatment of acute heart failure and its effect on serum brain natriuretic peptide

Objective To observe the clinical efficacy of levosimendan for the treatment of acute heart failure and its effect on serum brain natriuretic peptide.Methods Seventy-six patients with acute heart failure were randomly divided into observation group and control group,with 38 cases in each group.Besides the conventional therapy performed in both groups,the control group was given dobutamine hydrochloride injection for 7 days while the observation group was given levosimendan injection.Cardiac function parameters,incidence of adverse reactions and therapeutic effects were compared between the two groups before and after treatment.Results After 7 days of treatment,the level of brain natriuretic peptide was lower,stroke volume and left ventricular ejection fraction were higher in both groups compared to the indices before treatment,and the improvement in the observation group was more significant than that in the control group(all P<0.05).There were no significant differences in the incidence rate of adverse reactions between the two groups(P>0.05).The therapeutic effect in the observation group was better than that in the control group(P<0.05).Conclusion Levosimendan has a favorable effect on acute heart failure and can obviously down-regulate the serum level of brain natriuretic peptide,with a low incidence rate of adverse reactions.It is worth popularizing in clinical practice.