2型糖尿病患者血BUA、UAER水平与大血管病变的关系研究

目的 探讨2型糖尿病患者血尿酸(BUA)、尿微量白蛋白(UAER)与大血管病变的关系。方法 以本院2013年2月～2015年10月收治的100例2型糖尿病患者为研究对象,其中出现大血管病变53例,计为并发症组,无大血管病变47例,计为常规组,同时选择同期行健康体检50例人群为对照组,比较三组血糖、血压、血脂、BUA及UAER水平。结果 与对照组比较,并发症组、常规组患者收缩压、FPG、HbAlc、TC、TG、LDL-C水平明显高,差异有统计学意义(P＜0.05)。与常规组比较,并发症组HbAlc、LDL-C水平明显高,差异有统计学意义(P＜0.05)。三组血BUA[(362.5±112.0)vs(284.7±68.5)vs(180.4±103.0)]umol/L、UAER[(180.3±22.9)vs(68.2±12.2)vs(21.0±8.4)]mg/24h比较差异均有统计学意义(P＜0.05)。结论 2型糖尿病大血管病变患者表现出高血BUA、高UAER特点,可将血BUA、UAER水平作为2型糖尿病大血管病变风险预测因子之一。

Study on the relationship between BUA, UAER levels and macroangiopathy in patients with type 2 diabetes mellitus

Objective To investigate the relationship between blood uric acid (BUA), urinary albumin excretion rate (UAER) and macroangiopathy in patients with type 2 diabetes mellitus. Methods 100 cases of patients with type 2 diabetes mellitus who were admitted in our hospital between February 2013 and October 2015 were included in the study, including 53 cases with macroangiopathy (complication group) and 47 cases without (routine group). At the same time, 50 cases of healthy people who underwent physical examination were selected as the control group. The levels of blood glucose, blood pressure, blood lipid, BUA and UAER were compared between the three groups. Results The systolic blood pressure, levels of FPG, HbAlc, TC, TG and LDL-C of the complication group and the routine group were significantly higher than those of the control group (P < 0.05). The levels of HbAlc and LDL-C in the complication group were significantly higher than those in the routine group (P < 0.05). There were significant differences in BUA[(362.5±112.0) vs (284.7±68.5) vs (180.4±103.0)]umol/L and UAER[(180.3±22.9) vs (68.2±12.2) vs (21.0± 8.4)]mg/24h between the three groups (P < 0.05). Conclusions Type 2 diabetic patients with macroangiopathy showed high BUA and UAER. BUA and UAER levels can be used as one of the risk predictors of macroangiopathy in type 2 diabetes mellitus.