神经退行性疾病状态下血-脑屏障变化机制及中药对血脑屏障的影响研究进展 |
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引用本文: | 张伟,石海莲,吴晓俊,杨睿,王峥涛,刘梅. 神经退行性疾病状态下血-脑屏障变化机制及中药对血脑屏障的影响研究进展[J]. 安徽医药, 2016, 20(9): 1621-1625 |
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作者姓名: | 张伟 石海莲 吴晓俊 杨睿 王峥涛 刘梅 |
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作者单位: | 上海中医药大学中药研究所,上海 201203;上海中医药大学中药产学研合作中心,上海 201203;上海中医药大学中药研究所,上海,201203;上海中医药大学中药产学研合作中心,上海,201203 |
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基金项目: | 教育部高等学校博士学科点专项科研基金优先发展领域项目(20123107130002);上海高校特聘教授(东方学者)岗位计划资助(2013-59);上海教委科研创新重点项目(13ZZ099) |
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摘 要: | 血-脑屏障(BBB)结构和功能的完整性是维持中枢神经系统动态平衡的关键因素。BBB异常伴随神经退行性疾病的发展过程,不同的神经退行性疾病,其BBB异常的病理机制不同,而药物对BBB异常的改善作用也严重影响药物对神经退行性疾病的疗效。本文主要针对神经退行性疾病状态下BBB异常的分子机制及中药的调控作用及其机制两方面进行综述,为神经退行性疾病靶向血脑屏障药物的研发提供基础理论参考
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关 键 词: | 血脑屏障/药物作用 阿尔茨海默病 多发性硬化 帕金森障碍 中草药 综述 |
收稿时间: | 2016-03-30 |
修稿时间: | 2016-05-31 |
Research progress of mechanism of blood-brain barrier abnormity induced by neurodegenerative diseases and the effect of traditional Chinese medicine on blood-brain barrier abnormity |
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Abstract: | The integrity of structures and functions of blood-brain barrier(BBB)is critical determinant of central nervous system(CNS)homeostasis.The blood-brain barrier permeability was damaged under condition of disease, the blood-brain barrier will be hyper permeability and pathological changes in different disease with different mechanisms. This paper focuses on neurodegenerative diseases molecular mechanism of abnormal state of blood-brain barrier and the effect of traditional Chinese medicine (TCM) and its mechanism two aspects were summarized, this will promot targeted drug of blood-brain barrier of basic theoretical reference for the research and treatment of neurodegenerative disease. |
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Keywords: | Blood-brain barrier/drug effects Alzheimer disease Multiple sclerosis Parkinsonian disorders Drugs,chinese herbal Review |
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