冠状动脉内注射美托洛尔对介入性心肌损伤的保护作用 |
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引用本文: | 张焕基,许香广,张东辉,胡雪松,周文娟,吴施惠. 冠状动脉内注射美托洛尔对介入性心肌损伤的保护作用[J]. 中国实用医药, 2009, 4(32): 13-14 |
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作者姓名: | 张焕基 许香广 张东辉 胡雪松 周文娟 吴施惠 |
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作者单位: | 深圳市福田人民医院心内科,518033 |
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摘 要: | 目的研究冠状动脉内注射美托洛尔对介入性心肌损伤的保护作用。方法将86例行冠状动脉介入治疗(PCI)的患者随机分为试验组和对照组。两组在PCI前向冠状动脉内分别注射美托洛尔2rag(1mg/ml)和同等容积的生理盐水安慰剂。测定术前1h、术后6h、术后24h的血清肌钙蛋白I(cTNI)、肌酸激酶同工酶MB(CKMB)的变化,记录患者的胸痛症状以及心率、血压变化和球囊(或支架)的扩张压力、扩张次数。结果对照组与试验组之间cTNI、CKMB比较差异有统计学意义(P=0.004,0.003);两组的心率、血压和扩张压力、扩张次数比较差异均无统计学意义(P〉0.05)。冠状动脉内注射2mg美托洛尔未见明显的不良反应。结论冠状动脉内注射小剂量美托洛尔是安全有效的。在介入治疗时能在一定程度上有效地保护心肌细胞,减少心肌细胞的损伤;其对心率、血压影响不明显。
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关 键 词: | 冠状动脉介入治疗 美托洛尔 心肌损伤 冠状动脉内 |
The Protective Effectiveness of Intracoronary Metoprolol for Intervention-Related Myocardial Injury |
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Affiliation: | ZHANG Huan-ji, XU Xiang-guang, ZHANG Dong-hui, et al.( Shenzhen Futian people' s hospital, Shenzhen , Guangdong 518033, China ) |
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Abstract: | Objective To explore the cardial protective efficacy and safety of intracoronary metoprolol in patients undergoing percutaneous coronary intervention(PCI). Methods Patients ( n = 86) were randomly assigned to receive intracoronary metoprolol ( n = 46) or placebo ( n = 40). Both of them were delivered via an intracoronary catheter to the coronary lesion before PCI. cTNI and CKMB were detected at 1 h before PCI and 6 h, 24 h after PCI. Record the chest pain, heart rate, blood pressure, dilation times and pressure. Results There was a significant difference between two groups in cTNI ( P = 0. 004) and CKMB ( P = 0. 003 ). The heart rate and blood pressure weren' t affected obviously. No side effects were observed during PCI process. Conclusions Intracoronary metoprolol may reduce the injury of myocardial cell during PCI by enhancing the anti-myocardial ischemic effect. It doesn' t affect the heart rate and blood pressure obviously. |
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Keywords: | Percutaneous coronary intervention Metoprolol Myocardial injury Intracoronary |
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