胎儿宫内发育迟缓时孕妇及胎儿生长激素,胰岛素与甲状腺激素？…

目的 搪塞胎儿宫内发育迟缓（ＩＵＧＲ）时孕妇血清、脐血和羊水中生长激素、胰岛素及甲状腺激素的变化,方法 采用放射免疫和因相微球放射免疫法测定正常足月妊娠４２例（正常组）和足月妊娠ＩＵＧＲ２３例（ＩＵＧＲ）组）孕妇血清、脐血和羊水中生长激素、胰岛素、三碘甲腺原氨酸（Ｔ３）、甲状腺素（Ｔ４）和促甲状腺素（ＴＳＨ）水平。结果 ＩＵＧＲ组孕妇血清和脐血中生长激素显著下降,脐血和羊水中胰岛素水平与正常组比较

Correlation of intrauterine growth retardation with endocrine parameters

OBJECTIVE: To investigate the relationship between intrauterine growth retardation (IUGR)and endocrine parameters and to assess the effects of the main endocrine factors on IUGR. METHODS: The concentrations of growth hormone (GH), insulin, triiodothyronine (T(3)), tetraiodothyronine (T(4)), and thyroid-stimulating hormone (TSH) were measured in maternal serum, umbilical blood and amniotic fluid. The samples were collected from 23 term pregnancies with IUGR, and 42 normal pregnancies served as control. Growth hormone and insulin were measured by radioimmunoassay, and T(3), T(4) and TSH by microradioimmunoassay. RESULTS: The concentrations of GH, insulin and T(4) in umbilical blood were lower in IUGR group than that in the normal group (IUGR: GH 4.63 microg/L vs 7.01 microg/L, insulin 10.68 mIU/L vs 31.44 mIU/L, T(4) 0.68 mg/L vs 1.07 mg/L. P < 0.05, 0.05, 0.05), the TSH level in umbilical blood was higher in IUGR than that in the control group (10.84 mIU/L vs 5.74 mIU/L. P < 0.01). The concentration of GH in maternal serum and insulin in amniotic fluid in IUGR group were also lower than that in normal group (GH 1.77 microg/L vs 2.74 microg/L, P < 0.01; insulin 5.84 mIU/L vs 15.64 mIU/L, P < 0.01). CONCLUSIONS: This study confirms previous observation that insufficiency of GH might be a pathogenesis of IUGR. The decrease of GH and insulin might compromise the basic metabolism of the fetus. Besides, the change of early hypothyrosis of fetus with IUGR might benefit them to live in unfavorable environment.