2007年至2010年铜绿假单胞菌临床分布与耐药性分析

目的 分析铜绿假单胞菌的临床分布情况及耐药菌谱的变迁,为临床选用抗菌药物提供依据.方法 菌株鉴定严格按照《临床检验操作规程》进行操作,用K-B法进行药敏试验,数据采用WHONET 5.4和SPSS17.0统计软件进行统计分析.结果 铜绿假单胞菌主要分布丁ICU、呼吸科和神经科,并主要由痰标本检出.我院铜绿假单胞菌对阿米卡星、庆大霉素和莫西沙星的耐药率明显降低.环内沙星、亚胺培南、美洛培南、头孢他啶和头孢吡肟的耐药率有下降趋势.结论 铜绿假单胞菌是引起院内感染的常见致病菌,ICU、呼吸科、神经科最常见,痰标本分离率最高,四年来我院铜绿假单胞菌对大多数抗菌药物的耐药率均有下降趋势.

Clinical distribution and drug resistance of pseudomonas aeruginosa during 2007-2010

Objective To analyze the clinical distribution and drug resistance of pseudomonas aeruginosa and to provide some evidences for select antimicrobial drugs. Methods Strains were identi- fied strictly according to the National Clinical Laboratory Operation Guides. The susceptibility was tested with K-B method and analyzed with WHONET 5.4 and SPSS 17.0 software. Results Pseudomonas aeruginosa mainly distributed at ICU, department of respiratory medicine, department of neurology. And most of the strains were obtained from sputum. The resistance rate of pseudomonas aeruginosa to amikacin, gentamicin, and moxifloxacin in our hospital was decreased markedly. The resistance rate to ciprofloxacin, imipenem, meropenern, ceftazidime, and cefepime showed a downward trend. Conclusions Pseudomo- nas aeruginosa is a common pathogenic bacteria at hospital, especially at ICU, the department of respira- tory medicine, and department of neurology. The isolation rate of pseudomonas aeruginosa in sputum was the highest in all kinds of samples. Among these four years, the resistance rates of pseudomonas aeruginosa to most antimicrobial drugs showed a downward trend at our hospital.