Possible melatonin involvement in the hypotensive effect of MAO inhibitors |
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| Authors: | G. F. Oxenkrug R. B. McCauley D. J. Fontana I. M. McIntyre R. L. Commissaris |
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| Affiliation: | (1) Departments of Psychiatry, College of Pharmacy and Allied Health Professions, Wayne State University, USA;(2) Department Pharmacology, School of Medicine, College of Pharmacy and Allied Health Professions, Wayne State University, USA;(3) Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Wayne State University, USA;(4) Present address: Psychoendocrine Research Unit, Lafayette Clinic, Detroit, Michigan, USA |
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| Abstract: | Summary Effect of selective inhibitors of MAO-A and B isoenzymes on pineal melatonin (and related indoles), arterial blood pressure and brain MAO-A and B activities has been evaluated in intact, pinealectomized and shamoperated rats.Selective inhibition of MAO-A but not MAO-B activity stimulated pineal melatonin synthesis and decreased arterial blood pressure in intact and sham-operated animals. Pinealectomy attenuated the hypotensive effect of MAO-A inhibition.The possible melatonin contribution to both antidepressive and hypotensive effects of MAO inhibitors is discussed. |
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| Keywords: | Melatonin hypertension MAO |
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