| Prophylactic uses of integrin CD18-βA peptide in a murine polymicrobial peritonitis model |
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| 作者姓名： | José M Casasnovas |
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| 作者单位： | Kwong-Fai Wong(Department of Pharmacology and Surgery,National University Hospital System,National University of Singapore,Singapore 117597,Singapore;Department of Surgery,Queen Mary Hospital,Pokfulam,HKSAR,Hong Kong,China);Jana Wo,David Ho,Ronnie T Poon,John M Luk(Department of Surgery,Queen Mary Hospital,Pokfulam,HKSAR,Hong Kong,China);José M Casasnovas(Centro Nacional de Biotecnología,CSIC,Campus Universidad Autónoma,28049 Madrid,Spain) |
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| 基金项目： | Supported by Research Grants Council of Hong Kong,National University of Singapore and NMRC |
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| 摘 要： | AIM:To evaluate the prophylactic properties of integrin CD18-βA peptide in a murine model of abdominal polymicrobial peritonitis and sepsis.METHODS:Bacterial sepsis was induced in Institute of Cancer Research(ICR) mice by cecal ligation and puncture(CLP) surgery.Inflicted mice were then injected with either sterile saline or CD18-βA peptide intraperitoneally at 2 h after surgery,and were sacrificed at 12 and 24 h after surgery.Blood samples were immediately collected,and analyzed for endotoxin activity and ...
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| 关 键 词： | Bacterial endotoxin Integrin CD18 Inflammation Biotherapeutic peptide |
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