Design, synthesis, and evaluation of the antiproliferative activity of a series of novel fused xanthenone aminoderivatives in human breast cancer cells |
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Authors: | Giannouli Vasiliki Kostakis Ioannis K Pouli Nicole Marakos Panagiotis Kousidou Olga Ch Tzanakakis George N Karamanos Nikos K |
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Institution: | Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece. |
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Abstract: | Derivatives of two novel, structurally related heterocyclic ring systems, xantheno3,4-d]imidazole and chromeno4,3,2-c,d]imidazo4,5-f]indazole, bearing aminoalkyl side chains, have been synthesized, and their antiproliferative activity has been studied against the aggressive human breast MDA-MB-231 cell line. The pyrazole-fused analogue 27a possesses a pronounced antiproliferative effect on the tested cell line, evident at 1 muM, and achieves an IC50 of 6.5 microM. |
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