| 白芷总香豆素的药理作用研究 |
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| 引用本文： | 王梦月,贾敏如,马逾英,孙嘉敏,唐声武,蒋桂华,熊英.白芷总香豆素的药理作用研究[J].时珍国医国药,2005,16(10):954-956. |
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| 作者姓名： | 王梦月 贾敏如 马逾英 孙嘉敏 唐声武 蒋桂华 熊英 |
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| 作者单位： | 1. 成都中医药大学药学院,四川,成都,610075;上海交通大学药学院,上海,200030
2. 成都中医药大学药学院,四川,成都,610075 |
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| 基金项目： | 四川省科技厅资助项目（No.川科农2001[22]号）;致谢：在实验过程中得到了成都中医药大学药学院黄国钧教授、钟世红同学的大力帮助,在此表示谢意. |
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| 摘 要： | 目的：研究白芷总香豆素（AGC）药理作用。方法：运用柱层析方法，首次从白芷中提取总香豆素，并对白芷总香豆素类成分进行了抗炎、镇痛和解痉实验。结果：首次发现总香豆素类成分具有明显的镇痛和解痉作用，能明显对抗热板、冰醋酸所致小鼠疼痛及BaCl2所致兔肠平滑肌痉挛。结论：可为白芷临床应用提供依据。
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| 关 键 词： | 白芷 香豆素 镇痛 解痉 |
| 文章编号： | 1008-0805（2005）10-0954-03 |
| 收稿时间： | 2005-03-14 |
| 修稿时间： | 2005-08-05 |
Pharmacological Effect of the Total Coumarins in Radix Amgelicae dahuricae |
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| WANG Meng-yue,JIA Min-ru,MA Yu-ying,SUN Jia-min,TANG Sheng-wu,JIANG Gui-hua,XIONG Ying.Pharmacological Effect of the Total Coumarins in Radix Amgelicae dahuricae[J].Lishizhen Medicine and Materia Medica Research,2005,16(10):954-956. |
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| Authors: | WANG Meng-yue JIA Min-ru MA Yu-ying SUN Jia-min TANG Sheng-wu JIANG Gui-hua XIONG Ying |
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| Institution: | 1. Pharmacy School ,Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China 2. Pharmacy School, Shanghai Jiaotong University, Shanghai, 200030, China |
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| Abstract: | Objective:To study the pharmacological effect of the total coumarins of Baizhi.Methods:The total coumarins of Baizhi was extracted by column chromatograph and pharmacologic effects have been screened by anti-inflammation,analgestic and anti-spasticity experiments.Results:The total coumarins have obvious analgestic effect and they can decrease the mice's pain caused by hot board and actic acid.The total coumarins also have distinct anti-spasticity effect.They can significantly reparess rabbit intestine's spasm caused by BaCl_2.Conclusion:The pharmacological effect research can provide scientific basis for Baizhi clinical using. |
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| Keywords: | Angelica dahurica Coumarin Analgesic Anti-spasticky |
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