乳酸杆菌活菌制剂联合克霉唑治疗外阴阴道假丝酵母菌病的Meta分析

目的：运用Meta分析方法评价乳酸杆菌活菌制剂联合克霉唑治疗外阴阴道假丝酵母菌病的疗效。方法检索1966~2013年国内发表的乳酸杆菌活菌制剂联合克霉唑治疗外阴阴道假丝酵母菌病的随机对照试验，并使用Revman4.2软件进行分析。结果与克霉唑单一用药相比，联合乳酸杆菌活菌制剂治疗外阴阴道假丝酵母菌病疗效有统计学差异，RR合并值的点估计为1.06，可信区间为1.03～1.09（P=0.0001，即P＜0.05）；联合用药相比单一克霉唑，随访1、2、3个月后复发率均有统计学差异[RR=036，95%CI（0.20，0.66），Z=3.33，P=0.0009；RR=0.29，95%CI（0.13，0.61），Z=3.26，P=0.001；RR=0.26，95%CI（0.09，0.75）， Z=2.48，P=0.01]。结论乳酸杆菌活菌制剂联合克霉唑治疗外阴阴道假丝酵母菌病与单一克霉唑相比提高治疗效果，降低复发率。

Meta-analysis on live lactobacillus preparation plus clotrimazole for treatment of vulvovaginal candidiasis

Objective To evaluate the efficacy of live lactobacillus preparation plus clotrimazole on treatment of vulvovaginal candidiasis by Meta-analysis. Methods Randomized controlled trials on treatment of vulvovaginal candidiasis with live lactobacillus preparation plus clotrimazole published in China from 1966 to 2013 were retrieved for further analysis by Revman4.2 software. Results There was significant difference in the efficacy of vulvovaginal candidiasis treatment between live lactobacillus preparation plus clotrimazole and clotrimazole alone, with the point estimate of combined RR value of 1.06 and confidence interval of 1.03-1.09 （P=0.0001＆lt;0.05）. There was statistical significance between combined drug use and clotrimazole alone with regard to the recurrence rate within 1, 2, 3 months after follow-up [RR= 036, 95%CI （0.20, 0.66）, Z=3.33, P=0.0009; RR=0.29, 95%CI （0.13, 0.61）, Z=3.26, P=0.001;RR=0.26, 95%CI （0.09, 0.75）, Z=2.48, P=0.01]. Conclusion As for treatment of vulvovaginal candidiasis, live lactobacillus preparation plus clotrimazole has better therapeutic effects and lower recurrence rate than clotrimazole alone.