| ERK在大鼠浅筋膜中的表达及针刺后的改变特征 |
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| 引用本文： | 姜雪梅,杨春,原林,刁建新,张学全,黄泳,戴景兴,邱小忠,余磊. ERK在大鼠浅筋膜中的表达及针刺后的改变特征[J]. 南方医科大学学报, 2009, 29(4): 623 |
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| 作者姓名： | 姜雪梅 杨春 原林 刁建新 张学全 黄泳 戴景兴 邱小忠 余磊 |
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| 作者单位： | 1. 南方医科大学基础医学院,广东,广州,510515
2. 南方医科大学中医药学院,广东,广州,510515 |
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| 基金项目： | 国家重点基础研究发展规划(973计划) |
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| 摘 要： | 目的 探讨针刺对SD大鼠浅筋膜层的细胞外调节蛋白激酶(ERK1/2)表达情况的影响.方法 18只SD大鼠随机分为6组,对照组和针刺1、2、3、4、5组,每组大鼠3只.针刺各组在大鼠腹股沟区给予电针治疗后,分别在针刺后0、1、6、12和36 h等5个时间点取以针刺点为圆心,直径约1.5 cm处的浅筋膜,对照组也在针刺点相应的部位和足三里穴区取材.用Westernblot蛋白免疫印迹方法检测各组的ERK1/2及磷酸化ERK1/2(p-ERK1/2)的表达情况.结果 穴位和非穴区的浅筋膜的ERK1/2和p-ERK均有表达,但两者未见明显差异,针刺后各组针刺侧的ERK1/2的表达均明显高于自身对照侧.结论 正常的疏松结缔组织中可能通过ERK细胞信号转导蛋白的磷酸化来参与组织的增殖和分化;而针刺对于ERK信号转导有促进作用,这也可能是针灸对机体的病理和生理状态进行调控的机制之一.
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| 关 键 词： | 针刺 细胞外调节蛋白激酶 磷酸化细胞外调节蛋白激酶 筋膜 穴位/非穴 |
Expression of extracellular signal-regulated protein kinases in the subcutaneous fascia of rats and their changes after acupuncture |
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| JIANG Xue-mei,YANG Chun,YUAN Lin,DIAO Jian-xin,ZHANG Xue-quan,HUANG Yong,DAI Jing-xing,QIU Xiao-zhong,YU Lei. Expression of extracellular signal-regulated protein kinases in the subcutaneous fascia of rats and their changes after acupuncture[J]. Journal of Southern Medical University, 2009, 29(4): 623 |
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| Authors: | JIANG Xue-mei YANG Chun YUAN Lin DIAO Jian-xin ZHANG Xue-quan HUANG Yong DAI Jing-xing QIU Xiao-zhong YU Lei |
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| Affiliation: | JIANG Xue-mei1,YANG Chun1,YUAN Lin1,DIAO Jian-xin2,ZHANG Xue-quan1,HUANG Yong2,DAI Jing-xing1,QIU Xiao-zhong1,YU Lei1 1School of Basic Medical Sciences,2School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China |
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| Abstract: | Objective To observe the effect of acupuncture on the expression of extracellular signal-regulated protein kinases 1/2 (ERK1/2) in the subcutaneous fascia of SD rats. Methods Eighteen SD rats were randomly divided into 6 groups (n=3) including 5 acupuncture groups and a control group. The rats in the 5 acupuncture groups received electro-acupuncture therapy in the regions of the inguinal groove, and at 0, 1, 6, 12, and 36 h after the last therapy, the superfacial fascia surrounding the acupuncture point (ab... |
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| Keywords: | acupuncture extracellular signal-regulated protein kinases phosphorylated extracellular regulated protein kinases fascia acupoint/non-acupoint |
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