住院精神分裂症患者并发非酒精性脂肪肝的相关因素分析

目的 了解住院精神分裂症患者非酒精性脂肪肝的患病情况及相关因素.方法 对266例住院精神分裂症患者进行肝胆B超检查,心电图检查,并检测其空腹血糖、血脂、ALT、AST、GGT、AKP、LDH、UA等生化指标.结果 住院精神分裂症患者伴发非酒精性脂肪肝的比例为28.2％,远高于普通人群的患病率.BMI和TG值较大、EKG异常、患糖尿病、胆囊结石、是否服奥氨平与脂肪肝的患病与否等方面存在统计学意义.结论 住院精神分裂症患者伴发非酒精性脂肪肝的比例高,肥胖、高甘油三酯血症、EKG异常、糖尿病、胆囊结石、抗精神病药物是风险因素,值得临床关注.

The prevalence of non- alcoholic fatty liver disease in schizophrenia inpatients

Objective To investigate the prevalence of non- alcoholic fatty liver in schizophrenic inpatients and its related factors. Methods 266 schizophrenia inpatients treated in Shanghai Putuo Mental Health Center received ultrasonography of the liver. Serum level of several biochemical markers were measured,including fasting blood glucose, blood lipids, serum alanine aminotransferase （ALT） , aspartate aminotransferase（AST）,7-glutamyl transferase （GGT） ,alkaline phosphatase （AKP）,lactate dehydrogenase（LDH） and uric acid（UA）. Results The prevalence of non-alcoholic fatty liver in schizophrenic inpatients was 28. 2% , which is significantly higher than that of normal population. Higher BMI and TG,abnormal EKG, diabetes, and taking Olanzapine was related with no no-alcoholic fatty liver in schizophrenic inpatients. Conclusions No-alcoholic fatty liver occurs in many schizophrenia inpatients, especially in patients accompanying Obesity, diabetes, hypertriglyceridemia, abnormal EKG or taking psychotropic drugs. Attention should be paid to these relevant factors even in the early course of illness.