精神分裂症家族史性别差异调查

目的 了解不同性别精神分裂症遗传的差异及父系、母系阳性家族史的差异.方法 对长沙市城、乡在我院住院的及同时段各社区进行免费药物求助的共1938例精神分裂症患者进行精神障碍遗传的问卷调查,发现精神分裂症阳性家族史患者253例,其中男性139例,女性114例.对家族史阳性率,先证者父系、母系、同胞子女患病情况作统计分析.结果 男性阳性家族史比率较女性稍低,但无统计学意义；父系、母系、同胞子女的阳性家族史无明显性别差异；母系阳性家族史明显高于父系.结论 遗传因素对精神分裂症有很大的影响,不同性别精神分裂症的阳性家族史无明显差异.精神分裂症中母系后代比父系后代有更高的发病风险.

The investigation of familial gender difference in schizophrenia

Objective To investigate the familial risks of schizophrenia, the hereditary gender difference in schizophrenia and the hereditary difference between paternal and maternal cases were corn pared. Methods In 1 938 patients with schizophrenia 253 （male, 139; female, 114） had mental disorder family history. Their family history of mental disorders, detailed medical records of mental disorders in their matrilineal, maternal, sibling, and children of the probands and in probands were collected and ana- lyzed. Results Mental disorder family history was lower in male group compared with female group, but with no statistically significant difference between the two groups. Maternal transmission of psychotic disorder was stronger than that of paternal. Conclusions Hereditary factors have a strong influence on the onset of schizophrenia. There were no obviously differences between male group and female group. Maternal schizophrenia implied higher risks for the offspring.