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Synthesis and antifungal activity of new N-(1-phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides
Authors:Raffa Demetrio  Daidone Giuseppe  Plescia Fabiana  Schillaci Domenico  Maggio Benedetta  Torta Livio
Institution:Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Italy. demraffa@unipa.it
Abstract:N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity of the N-substitution with an aromatic heterocyclic system on benzamide moiety. Among the tested iododerivatives, compounds 6d,f,g,h possess interesting activities toward some phytopathogenic fungal strains.
Keywords:N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-2-iodobenzamides  N-(Indazol-3-yl)-2-iodobenzamides  N-(Indazol-5-yl)-2-iodobenzamides  Antifungal activity
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