|
|||||
|
|
| 原发性干燥综合征患者唇腺组织中CAD的表达与细胞凋亡的关系 | |
| 引用本文： | 王建光,杨新宇,王建敏,王佳珍. 原发性干燥综合征患者唇腺组织中CAD的表达与细胞凋亡的关系[J]. 中国老年学杂志, 2005, 25(8): 892-894 |
| 作者姓名： | 王建光 杨新宇 王建敏 王佳珍 |
| 作者单位： | 1. 温州医学院生化教研室,浙江,温州,325027 2. 温州医学院化学教研室 3. 佳木斯市中心医院风湿科 |
| 基金项目： | 浙江省青年教师资助计划项目 |
| 摘 要： | 目的 研究原发性干燥综合症（primary Sjgren＇s syndromepss）唇腺组织细胞中Fas介导的细胞凋亡信号转导相关蛋白的表达，探讨导致干燥综合征的细胞信号转导的可能途径。方法 采用Westernblot法检测唇腺组织中Fas、FasL蛋白的表达；RT-PCR半定量检测CAD mRNA表达。结果 与对照组比较pSS患者唇腺组织细胞中Fas介导的细胞凋亡信号转导相关蛋白Fas、FasL的表达及CADmRNA表达都有不同程度增高（P〈0．05）。结论 导致干燥综合征患者唇腺组织凋亡的信号转导途径可能是由Fas介导的。 |
| 关 键 词： | 干燥综合征 唇腺 细胞凋亡 CAD |
| 文章编号： | 1005-9202（2005）08-0892-03 |
| 收稿时间： | 2004-04-19 |
| 修稿时间： | 2004-04-19 |
Relationship between expression of caspase-activated DNase gene and neuronal apoptosis in labial gland of patients with primary sjogren syndrome |
|
| Wang JianGuang;Yang XinYu;Wang JianMin;Wang JiaZhe. Relationship between expression of caspase-activated DNase gene and neuronal apoptosis in labial gland of patients with primary sjogren syndrome[J]. Chinese Journal of Gerontology, 2005, 25(8): 892-894 | |
| Authors: | Wang JianGuang Yang XinYu Wang JianMin Wang JiaZhe |
| Abstract: | Objective To study the expression of related protein of apoptosis signaling transduction induced by Fas in labial salivary gland of patients with sjogren syndrome(pSS) , and to explore the possible pathway of cell signaling transduction resulting in pSS. Methods The expressions of Fas and FasL protein in labial salivary gland were determined with Western blotting; the expressions of caspase-antivated T)Nase(CAD) mRNA were measured by RT-PCR. Results The expressions of Fas, FasL and CAD mRNA in labial salivary gland of patients with pSS were significantly higher than those of controls( P < 0. 05 ) . Conclusions Signaling transduction pathway resulting in apoptosis of labial salivary gland in patients with pSS might be induced by Fas. |
| Keywords: | Sjogren syndrome Labial gland Apoptosis Caspase-activated DNase (CAD) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |