Specific gel-cream as adjuvant to oral isotretinoin improved hydration and prevented TEWL increase – a double-blind, randomized, placebo-controlled study |
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Authors: | Marí a Isabel Herane,MD,,Hé ctor Fuenzalida,MD,,Emilia Zegpi,MD,,Carolina De Pablo,QF,,Maria José Espadas,MS,,Carles Trullá s,MS,,Alfons Mirada,MD,,& Guillermo Gonzá lez Martin,QF |
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Affiliation: | Hospital Clínico Universidad de Chile, Santiago de Chile, Chile; Complejo Asistencial Barros Luco, Universidad de Chile y USACH, Santiago de Chile, Chile; Hospital Clínico Pontificia Universidad Católica de Chile, Santiago de Chile, Chile; Pontificia Universidad Católica de Chile, Santiago de Chile, Chile; Isdin, C/Provençals 33 08019-Barcelona, Spain |
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Abstract: | Background Hydrating and emollient products are often recommended to patients under isotretinoin therapy to control the most frequent mucocutaneous side effects and to improve adherence to treatment. Aims To assess, using noninvasive biophysical tests, the clinical and instrumental effectiveness of a hydrating gel-cream compared with placebo as an adjuvant to isotretinoin for treatment of facial skin in patients with inflammatory acne. Methods Prospective, double-blind, randomized study, using MULTI SKIN MC750, on the adjuvant effect of a hydrating gel-cream for acne (active product) vs. a gel-cream without active substances (placebo). Follow-up lasted 3 months. Results Sixty-six patients were included. Thirty-four were administered the active product, and 32 placebo. Though the number of lesions fell significantly in both groups, the mean number of papules on day 30 was significantly lower in the active product group. The active product group showed a significant increase in hydration, while the placebo group showed a significant increase in transepidermal water loss (TEWL). Seborrhoea decreased significantly in both groups; there were no differences between them. Conclusions Compared with placebo, the specific gel-cream with active products as an adjuvant to oral isotretinoin improved hydration, prevented TEWL increase, and reduced inflammatory acne lesions after 30 days. |
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Keywords: | acne treatment oral isotretinoin adjuvant treatment emollients gel-cream |
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