布地奈德联合沙丁胺醇雾化吸入治疗慢性阻塞性肺疾病急性加重期的临床效果观察

目的 观察布地奈德联合沙丁胺醇雾化吸入对慢性阻塞性肺疾病急性加重期（AECOPD）的临床疗效.方法 选择AECOPD患者96例,随机分为观察组48例和对照组48例.对照组在常规治疗基础上加用沙丁胺醇雾化吸入,观察组在常规治疗基础上加用布地奈德联合沙丁胺醇雾化吸入治疗.比较两组患者入院时及治疗7d后呼吸困难评分、动脉血气指标、肺功能指标及不良反应情况.结果 观察组呼吸困难评分低于对照组,动脉血气高于对照组,动脉血二氧化碳分压低于对照组,第1秒用力呼气容积（FEV1）绝对值和FEV1占预计值百分比高于对照组,差异均有统计学意义（P＜0.05）.两组患者治疗期间均无严重不良反应发生.结论 布地奈德联合沙丁胺醇雾化吸入治疗AECOPD效果显著,优于单用沙丁胺醇.

The clinical efficacy observation of budisonide comined with salbutamol atomization inhalation in treatment of acute exacerbation of chronic obstructive pulmonary disease

Objective To observe the clinical efficacy of budesonide combined with salbutamol atomization inhalation on acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods 96 patients with AECOPD were randomly divided into observation group （48 cases） and control group （48 cases）.In addition to the rutine treatment,pa- tients in control group were treated with salhutamol atomization inhalation and patients in observation group were treat- ed with the combination of budesonide and salbutamol atomization inhalation.Dyspnea score,aterial blood gas index,pul- monary function index and adverse reaction in the two groups were observed and cmpared after seven days treatment. Results Dysnea score in the observation group was lower than that of control group;arterial partial pressure of oxygen was higher than that of the control group,arterial partial pressure of carbon dioxide was lower than that of control group; and forced expiratory volume in one second （FEV 1） absolute value and FEV1% were higher than that of the control group,the differences were all statistically significant （P〈0.05）.All patients had no severe adverse reaction in the treat- ment. Conclusion The effects of budesonide combined with salbutamol atomization inhalation in treatment of AECOPD are more effective than the application of single sabutamol.