| 替代对照品法快速确证3种抗艾滋病药物 |
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| 引用本文： | 王军,陈金泉,权勤波,印成霞,何立环. 替代对照品法快速确证3种抗艾滋病药物[J]. 中国药师, 2014, 0(1): 4-8 |
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| 作者姓名： | 王军 陈金泉 权勤波 印成霞 何立环 |
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| 作者单位： | 东营市食品药品检验中心 山东东营 257091；;东营市食品药品检验中心 山东东营 257091；;东营市食品药品检验中心 山东东营 257091；;东营市食品药品检验中心 山东东营 257091；;山东大学第二医院 |
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| 基金项目： | 中国全球基金结核病整合项目［卫生系统加强（HSS）］部分 |
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| 摘 要： | 目的：建立替代对照品法快速确证茚地那韦、利托那韦、洛匹那韦的方法.方法：以利托那韦为参比物,采用有效相对保留时间和紫外光谱相似度双指标定性分析;采用相对校正因子进行定量分析.结果：建立了三种抗艾滋病药物的紫外光谱库;茚地那韦、利托那韦和洛匹那韦的有效相对保留时间分别为：0.466～0.518,1.000和1.664～1.840;茚地那韦、利托那韦和洛匹那韦的相对校正因子分别为0.858 7,1.000 0,0.752 0.结论：该方法快速、简便,适用于药品的快速检测,可作为近红外快筛技术确证方法.
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| 关 键 词： | 替代对照品法 抗艾滋药物 茚地那韦 利托那韦 洛匹那韦 快速确证 |
| 收稿时间： | 2013-08-06 |
| 修稿时间： | 2013-09-27 |
Fast Confirmation of Three Anti HIV Drugs by Replacement Method of Chemical Reference Substance |
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| Wang Jun,Chen Jinquan,Quan Qinbo,Yin Chengxia and He Lihuan. Fast Confirmation of Three Anti HIV Drugs by Replacement Method of Chemical Reference Substance[J]. China Pharmacist, 2014, 0(1): 4-8 |
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| Authors: | Wang Jun Chen Jinquan Quan Qinbo Yin Chengxia He Lihuan |
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| Affiliation: | Dongying Institute for Food and Drug Control, Shandong Dongying 257091, China;;Dongying Institute for Food and Drug Control, Shandong Dongying 257091, China;;Dongying Institute for Food and Drug Control, Shandong Dongying 257091, China;;Dongying Institute for Food and Drug Control, Shandong Dongying 257091, China;;The Second Hospital of Shandong University |
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| Abstract: | Objective： To establish a fast confirmatory method for indinavir, ritonavir and lopinavir by replacement method of chemical reference substance. Methods： Ritonavir was used as the reference, the effective relative retention time and spectral similarity were applied in the qualitative analysis, and the relative correction factor was employed in the quantitative analysis. Results： The ul- traviolet spectral library of the 3 anti-HIV drugs was established. The effective relative retention time of indinavir, ritonavir and ]opina- vir was 0. 466-0. 518, 1. 000 and 1. 664-1. 840, respectively. The relative correction factor of indinavir, ritonavir and lop＇inavir was 0. 858 7,1. 000 0 and 0. 752 0,respectively. Conclusion： The method is rapid and simple, and suitable for the rapid determination of drugs after NIR screening. |
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| Keywords: | Replacement method of chemical reference substance Anti-HIV drugs Indinavir Ritonavir Lopinavir Fast confir- mation |
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