| 神经胶质瘤中细胞增殖核抗原Ki-67的表达及研究 |
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| 引用本文： | 林英,郝卓芳,黄世章,廖德贵. 神经胶质瘤中细胞增殖核抗原Ki-67的表达及研究[J]. 国际医药卫生导报, 2005, 11(16): 13-14 |
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| 作者姓名： | 林英 郝卓芳 黄世章 廖德贵 |
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| 作者单位： | 广州医学院第二附属医院病理科,广东,广州,510260;广州医学院第二附属医院病理科,广东,广州,510260;广州医学院第二附属医院病理科,广东,广州,510260;广州医学院第二附属医院病理科,广东,广州,510260 |
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| 摘 要： | 目的探讨神经胶质瘤组织中Ki-67抗原表达及其与肿瘤发生和恶性程度的关系。方法应用免疫组化Envision法对39例颅内神经胶质细胞瘤标本中Ki-67抗原的表达进行检测，观察Ki-67与神经肿瘤恶性程度间的关系。结果不同恶性程度胶质细胞瘤间Ki-67表达强度有明显差异（F=36．375，P〈0．05），与肿瘤的恶性程度呈正相关（r=0．939，R〈0．05）。结论细胞增殖核抗原Ki-67的表达与胶质瘤的发生及其恶性程度有一定关系，临床检测Ki-67指数有助于患者预后评估。
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| 关 键 词： | 神经胶质瘤 Ki-67 免疫组织化学 |
| 文章编号： | 1007-1245（2005）16-0013-02 |
| 收稿时间： | 2005-03-18 |
| 修稿时间： | 2005-03-18 |
A Study and Expression of the Ki-67 Proliferation Nuclear Antigen in Gliomas |
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| Lin Ying,Hao ZhuoFang,Huang shizhang,Liao degui. A Study and Expression of the Ki-67 Proliferation Nuclear Antigen in Gliomas[J]. International Medicine & Health Guidance News, 2005, 11(16): 13-14 |
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| Authors: | Lin Ying Hao ZhuoFang Huang shizhang Liao degui |
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| Abstract: | Objective To explore the Ki-67 expression in human gliomas and its implication to tumorigenesis and the degree of gliomas' malignancy.Methods After Ki-67 antigen expression in 39 gliomas were determined by immunohistochemical technique, we evaluate the relation Ki-67 expression and the one between the degree of gliomas' malignancy. Results The expression of ki-67 antigen were significantly different (F= 36.375, P<0.05), and had a positive correlation with the malignant degrees (r=0.939, P<0.050). Conclu- sions The expression Ki-67 antigen could be related to the tumorigenesis and the degrees of malignancy of human brain gliomas. The Ki-67 L1 detected will provide more useful infonmation for patient's prognosis. |
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| Keywords: | Gliomas Ki-67 Immunohistochemical |
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