Effect of iontophoresis on in vitro transdermal absorption of almotriptan |
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Authors: | Calatayud-Pascual M A Balaguer-Fernández C Serna-Jiménez C E Del Rio-Sancho S Femenía-Font A Merino V López-Castellano A |
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Institution: | a Departamento de Fisiología, Farmacología y Toxicología, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Seminario s/n, 46113 Moncada, Spain b Centro de Reconocimiento Molecular y Desarrollo Tecnológico, Unidad Mixta Universidad Politécnica de Valencia-Universidad de Valencia, Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Valencia, 46100 Burjasot, Valencia, Spain |
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Abstract: | The aim of the present work was to characterize the in vitro transdermal absorption of almotriptan through pig ear skin. The passive diffusion of almotriptan malate and its iontophoretic transport were investigated using current densities of 0.25 and 0.50 mA/cm2. In vitro iontophoresis experiments were conducted on diffusion cells with an agar bridge without background electrolytes in the donor compartment. Although both current densities applied produced a statistically significant increment with respect to passive permeation of almotriptan (p < 0.01), that of 0.50 mA/cm2 proved to be the best experimental condition for increasing the transport of almotriptan across the skin. Under these experimental conditions, the transdermal flux of the drug increased 411-fold with respect to passive diffusion, reaching 264 ± 24 μg/cm2 h (mean ± SD). Based on these results, and taking into account the pharmacokinetics of almotriptan, therapeutic drug plasma levels for the management of migraine could be achieved via transdermal iontophoresis using a reasonably sized (around 7.2 cm2) patch. |
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Keywords: | Almotriptan Migraine Transdermal drug administration Iontophoresis Current density Patch |
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