Implication of serotonin-transporter (5-HTT) gene polymorphism in subjective memory complaints and mild cognitive impairment (MCI) |
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Authors: | Sandro Marini Silvia Bagnoli Valentina Bessi Andrea Tedde Laura Bracco Sandro Sorbi Benedetta Nacmias |
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Affiliation: | a Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, I-50134 Florence, Italy b Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Viale Morgagni 85, I-50134 Florence, Italy |
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Abstract: | Serotonin-transporter-linked polymorphism (5-HTTLPR) is involved in neuropsychiatric diseases and recently the S-isoform has been correlated with a higher risk of developing emotion-induced retrograde amnesia. In order to better clarify the possible role of the 5-HTT S/L polymorphism and its effects on cognitive ability, especially on memory skills, we report here the distributions of the 5-HTT genetic variant and the Apolipoprotein E (ApoE) ?-4 allele and their association with neuropsychological measures in older adults reporting problems with everyday memory. Moreover, we verified the presence of a possible association between the S-allele with depression and the personal trait of neuroticism. Our results indicate an association between the 5-HTTLPR S-allele and the risk of developing MCI. No association was found in the other three groups. We found a positive dose-dependent association between the S-allele and the Rey-Osterrieth complex figure test (recall) score. Finally, our data did not find an association between the same allele and depression or neuroticism. This data, in our opinion shows a slight, non-established influence of 5-HTTLPR on memory skills exhibited in challenging memory tests but no influence on other extra-mnesic cognitive abilities. |
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Keywords: | Serotonin transporter (5-HTT) Mild cognitive impairment (MCI) Subjective memory complaints (SMC) Episodic memory |
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