Measures of exercise capacity in adults with congenital heart disease |
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Authors: | Roselien BuysVéronique Cornelissen Alexander Van De BruaeneAn Stevens Ellen CoeckelberghsSteven Onkelinx Tom ThomaesChristophe Delecluse Werner BudtsLuc Vanhees |
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Institution: | a Research Centre for Cardiovascular and Respiratory Rehabilitation, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101 bus 1501, 3001 Heverlee, Belgiumb Internal Medicine, Division of Cardiology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgiumc Research Centre for Exercise and Health, Department of Biomedical Kinesiology, Katholieke Universiteit Leuven, Tervuursevest 101 bus 1501, 3001 Heverlee, Belgium |
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Abstract: | BackgroundExercise capacity in grown-ups with congenital heart disease (GUCH) is mostly reported by peak oxygen consumption (peak VO2). Our aim was to evaluate the maximal character of exercise tests, and to investigate submaximal measures of exercise capacity.MethodsAdults with Coarctation of the Aorta (COA, n = 155), Tetralogy of Fallot (TOF, n = 98), dextro-Transposition of the Great Arteries (dTGA, n = 68) and Univentricular Heart (UVH, n = 10), and 122 healthy adults performed cardiopulmonary exercise testing until exhaustion. Gas exchange was measured breath by breath. The maximal performance of the test was evaluated by respiratory exchange ratio (RER), ventilatory equivalent for oxygen and Borg scale. Oxygen uptake efficiency slope (OUES), VE/VCO2 slope and VO2/WR slope were calculated and ventilatory anaerobic threshold (VAT) was defined. Correlations of these measures with peak VO2 were calculated.ResultsGUCH showed significantly lower peak VO2 than controls (p < 0.001), declining from 80% in COA, 74% in TOF, 64% in dTGA, to 55% in UVH. Compared to suggested criteria, mean peak RER and median Borg scale indicated a maximal effort in GUCH, however these results were significantly lower than controls (p < 0.05). OUES, VO2/WR slope and VAT were significantly lower in patients compared to controls. OUES (r = 0.853) and VAT (r = 0.840) correlated best with peak VO2; VO2/WR slope (r = 0.551) and VE/VCO2 slope (r = −0.421) correlated to a lesser degree (p < 0.001).ConclusionThe investigated GUCH show reduced exercise tolerance compared to controls, related to the underlying heart defect. Different expressions of exercise tolerance clearly reveal the same differences in exercise capacity across groups of GUCH. |
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Keywords: | Adult congenital heart disease GUCH Exercise capacity Oxygen uptake efficiency slope Ventilatory anaerobic threshold |
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