栀子中京尼平苷及藏红花素的神经保护作用研究进展

栀子是茜草科栀子属植物Gardenia jasminoides的成熟果实,栀子作为药食两用资源,一直备受关注。栀子的活性成分包括京尼平苷和藏红花素,研究证明其具有多种生理活性。综述了这2种主要功能性成分对中枢神经系统的保护作用及其机制的研究进展,包括对阿尔茨海默病、帕金森病和脑缺血等疾病以及学习、记忆等功能的改善作用,为栀子的进一步开发利用提供了依据。

Research progress on neuroprotective effects of geniposide and crocin from fruits of Gardenia jasminoides

Gardeniae Fructus is the mature fruit of Gardenia jasminoides from genus Gardenia Ellis, nom. cons., Rubiaceae Family. The fruit of G. jasminoides is one of the widely used Chinese herbals and also can be used as edible resource. Geniposide and crocin are the two mainly components in the fruit, and some bioactivities of them had been proved. The protective effects and their mechanism of geniposide and crocin on the central nervous system were summarized in this paper, including diseases (Alzheimer''s disease, Parkinson''s disease and cerebral ischemia) and physiologic function (learning and memory), which was helpful to develop and utilize the fruit.