甜梦胶囊联合帕罗西汀治疗女性更年期广泛性焦虑障碍临床疗效

目的研究甜梦胶囊联合帕罗西汀治疗女性更年期广泛性焦虑障碍效果及抗氧化应激反应机制。方法选择120例诊断为更年期广泛性焦虑障碍患者,未用雌激素替代治疗,随机分为对照组和治疗组各60例,对照组采用帕罗西汀治疗,治疗组在对照组基础上口服甜梦胶囊,30 d为1个疗程,对比临床效果。结果两组治疗后,汉密尔顿焦虑量表(HAMA)评分和匹兹堡睡眠质量指数量表(PSQI)评分均较治疗前明显降低,且治疗组评分低于对照组(P0.05)。治疗组的总有效率和显效程度明显优于对照组(P0.05)。两组均未出现明显药物不良反应。两组治疗前后组间血清卵泡刺激素(FSH)、黄体生成素(LH)和雌二醇(E_2)水平比较无差异(P0.05)。两组治疗后血清超氧化物歧化酶(SOD)水平较治疗前升高,丙二醛(MDA)水平降低,且治疗组改善程度大于对照组(P0.05)。结论帕罗西汀联合甜梦胶囊治疗更年期广泛性焦虑障碍安全、有效,不依赖性激素水平改善,可能与氧化应激反应有关。

Clinical efficacy of Tianmeng Capsule combined with paroxetine in treatment of menopausal women with generalized anxiety disorder

Objective To study the effect of Tianmeng Capsule combined with paroxetine in the treatment of menopausal women with generalized anxiety disorder (GAD) and its mechanism of the reaction with oxidative stress. Methods Totally 120 cases of menopausal patients with GAD, without the use of estrogen replacement therapy, were randomly divided into control group and observation group of 60 cases, the control group were treated with paroxetine, the observation group were additionally treated with Tianmeng Capsule, then the clinical effects were compared. Results The Hamilton anxiety scale (HAMA) scores and Pittsburgh sleep quality index scale (PSQI) scores were significantly decreased in two groups and the indexes in the observation group were lower than control group (P<0.05). The total effective rate in the observation group was significantly better than that of the control group (P<0.05). There were no obvious adverse drug reactions in the two groups. The serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E₂) levels had no significant difference between two groups after treatment. The serum superoxide dismutase (SOD) levels increased, and malondialdehyde (MDA) levels decreased in the observation group (P<0.05). Conclusion It is safe and effective to treat GAD patients with Tianmeng Capsule, which may not improve the level of hormone but related to oxidative stress.