| 高压氧治疗在神经修复与再生过程中的作用及分子学机制 |
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| 引用本文： | 余海,田润兰,潘小雯,栾佐,宋连文. 高压氧治疗在神经修复与再生过程中的作用及分子学机制[J]. 中国组织工程研究与临床康复, 2001, 5(5): 48-49 |
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| 作者姓名： | 余海 田润兰 潘小雯 栾佐 宋连文 |
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| 作者单位： | 1. 解放军海军总医院,
2. 军事医学科学院二所 |
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| 摘 要： | 目的研究高压氧(HBO)治疗对7日龄鼠缺血缺氧性脑损伤后碱性成纤维生长因子(bFGF)及其mRNA表达的影响。方法建立新生鼠缺血缺氧性脑病模型，应用HBO治疗后应用免疫组织化学技术检测脑bFGF表达，应用原位杂交技术检测脑bFGFmRNA。结果HBO组bFGF表达及bFGFmRNA表达均显著增强，而高压空气(HBA)组脑bFGF表达增强，bFGFmRNA表达减弱。结论HBO增强新生鼠缺血缺氧性脑损伤后bFGF及其mRNA表达。
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| 关 键 词： | 高压氧；脑缺血缺氧性脑损伤；碱性成纤维生长因子 |
| 文章编号： | 1007-5496(2001)03-0048-02 |
| 修稿时间： | 2001-01-03 |
The effect of hyperbaricoxygen therapy on recvery and regeneration of nerve and molecular mechanism |
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| YU Hai,TIAN Run- can, PAN Xiao- wen,et al.. The effect of hyperbaricoxygen therapy on recvery and regeneration of nerve and molecular mechanism[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2001, 5(5): 48-49 |
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| Authors: | YU Hai TIAN Run- can PAN Xiao- wen et al. |
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| Affiliation: | YU Hai,TIAN Run- can, PAN Xiao- wen,et al.Naval General hospital,Beijing 100037,China |
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| Abstract: | Objective To study the effect of hyperbaric oxygen on basic fibroblast growth factor(bFGF) and bFGF mRNA expression in7- day old neonatal rats after brain hypoxia-ischemia injury. Method Brain hypoxia-ischemia injury in neonatal rats was established byRice' method After HBO treatment, bFGF expression was investigated by means of immunohistochemical analysis, and bFGF mRNA by means ofin situ hybridization. Result bFGF exprssion were higher in both HBO and HBA groups than in the free growing group and controls. However,bFGF mRNA expression increased only in HBO groups. Conclusion HBO increased both bFGF and bFGF mRNA expression of neonatal ratsafter brain hypoxia-ischemia injury. |
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| Keywords: | hyperbaric oxygen brain hypoxia- ischemia injury basic fibroblast growth factor(bFGF) |
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