| WNT信号转导在肝细胞癌发病中的作用 |
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| 引用本文： | 吴龙,钱叶本. WNT信号转导在肝细胞癌发病中的作用[J]. 医学研究生学报, 2007, 20(6): 651-655 |
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| 作者姓名： | 吴龙 钱叶本 |
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| 作者单位： | 安徽医科大学第一附属医院肝胆外科,安徽,合肥,230022 |
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| 基金项目： | 安徽省教育厅自然科学基金 |
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| 摘 要： | Wnt蛋白及其受体、调节蛋白等一起组成了复杂的信号通路，它与胚胎正常发育、细胞的增殖与分化以及肿瘤形成密切相关。Wnt信号通路与肝细胞癌的关系，近年来受到广泛关注，得到了深入的研究。作者就Wnt信号通路及其调节蛋白之间相互作用，Wnt信号通路与肝细胞癌发生发展、血管形成、侵袭和转移等方面的关系作一综述。
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| 关 键 词： | Wnt信号通路 肝细胞癌 血管生成 侵袭 转移 |
| 文章编号： | 1008-8199（2007）06-0651-05 |
| 收稿时间： | 2006-12-26 |
| 修稿时间： | 2006-12-262007-02-05 |
Role of Wnt signaling pathway in hepatocellular carcinoma |
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| WU Long,QIAN Ye-ben. Role of Wnt signaling pathway in hepatocellular carcinoma[J]. Bulletin of Medical Postgraduate, 2007, 20(6): 651-655 |
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| Authors: | WU Long QIAN Ye-ben |
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| Affiliation: | Department of Hepatobiliary Surgery, the First Affiliated Hospital of Anhui 230022,Anhui, China |
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| Abstract: | Wnt proteins, its receptors and regulators compose complex signaling pathways which are closely related to embryonic development, cell proliferation and differentiation, as well as tumour generation. In recent years, the involvement of Wnt signaling pathways in hepatocarcinogenesis has drawn the attention of international medical circles and been studied intensively. In this review, we summaries the interaction between Wnt signaling pathways and its regulators, the relationship between Wnt signaling pathways and cancerogenesis, angiogenesis, invasion and metabasis in hepatocellular carcinoma. |
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| Keywords: | Wnt signaling pathways Hepatocellular carcinoma Angiogenesis Invasion Metabasis |
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