浆细胞样树突状细胞在肝脏疾病中的作用

浆细胞样树突状细胞(pDCs)在外周血中所占比例很小,其选择性地表达Toll样受体TLR7和TLR9。pDCs在接受病原体刺激后快速产生大量Ⅰ型干扰素,产生干扰素之后,pDCs通过激活传统树突状细胞、T细胞、自然杀伤细胞和B细胞形成保护性免疫反应,pDCs分化成为成熟树突状细胞,pDCs抗原提呈能力能够连接天然免疫和获得性免疫反应。已经有报道表明pDCs在病毒感染和癌症中发挥作用。本文中我们综述pDCs在肝脏疾病中的作用。

The role of plasmacytoid dendritic cells in liver diseases

Plasmacytoid dendritic cells （pDCs） are a rare population of circulating cells that selectively express Toll-like receptors TLR7 and TLR9, they are specialized in rapid massive secretion of type Ⅰ interferon in response to pathogenic agents or danger signals. Through the production of type ⅠIFNs, pDCs initiate protective immunity by activating classical DCs, T cells, natural killer cells and B cells. Upon activation, pDCs differentiate into mature DCs. Combined with their antigen presentation capacity, this powerful functionality enables pDCs to orchestrate innate and adaptive immune responses. It has been demonstrated that pDCs can coordinate events during the course of viral infections and cancer. Here we reviewed select aspects of pDC biology involved in liver diseases.