谷氨酰胺对急性期脑卒中并发症的影响研究

目的:探讨谷氨酰胺对脑卒中急性期营养状况恶化和感染性并发症的影响。方法:收集临床住院脑卒中急性期病例86例,脑出血29例、脑梗死57例,实验组给予谷氨酰胺治疗,其余治疗内容与对照组相同;随后动态记录病程 28天内感染性并发症的发生及持续时间,以及不同时间点的营养学指标。结果:(1)在脑卒中急性期对照组的感染性并发症的发生率及持续时间均较实验组明显严重。(2)对照组营养状况的恶化程度明显较实验组重。结论:脑卒中急性期使用谷氨酰胺具有预防感染性并发症的发生和发展,其机制可能与减轻营养状况的恶化和增强机体的抵抗力相关。

Effect of Parenteral Glutamine Peptide Supplements on the Infective Complication and the Deterioration of Nutrition Status following Acute Stroke

Objective: To study the effects of glutamine peptide on the infective complication and the deterioration of nutrition status following acute stroke. Methods: The study included 57 patients with cerebral ischemia and 29 patients with cerebral hemorrhage that was in less than 24 hours duration. Nutritional parameters were evaluated at admission and after 2 weeks following stroke respectively. Neurological deficit was also evaluated by the Chinese Stroke Scale at admission. The infective complications were investigated. Results: At the same duration after acute stroke, the infectious morbidity was significantly higher and it's duration was significantly longer in the contral group than the glutamine peptide group. The degree of nutriture deteriorating was significantly severer in the contral group than the glutamine peptide group at the same duration following acute stroke. Conclusions: 1. Parenteral Glutamine Peptide supplements is helpful for the controling infective complication and preventing deterioration of nutrition status following acute stroke. 2. The effects of glutamine peptide on the infective complication may be result from altering immune functions, preventing nutriture deterioration in secondary acute stroke.