Effects of Schisandra chinensis Baillon (Schizandraceae) on lipopolysaccharide induced lung inflammation in mice |
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| Authors: | Bae Hyunsu Kim Ranah Kim Youngeun Lee Euijeong Jin Kim Hye Pyo Jang Young Jung Sung-Ki Kim Jinju |
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| Affiliation: | Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, China. |
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| Abstract: | Aim of the studyThis study was aimed to evaluate the neuroprotective and anti-aging activity of extracts in Caenorhabditis elegans from the roots and leaves of Damnacanthus officinarum Huang to provide the pharmacological basis in traditional medicine.Materials and methodsInvestigations on the neuroprotective and lifespan activity were carried out, which were observed by utilizing the following models: observing the worms’ chemosensory behavior test based on the aversion index in the assay plate, neuroprotective activity of nematode by evaluating the ASH neuron survival and lifespan test in C. elegans.ResultsIt has been shown that the ethanol, n-butanol and aqueous extracts in the roots possessed significantly neuroprotective effect both in chemosensory behavior test and ASH neuron survival model. The same extracts in the leaves showed similar activities in two models, but have less potency revealing by the data. Four candidate extracts, possessing excellent neuroprotective activity, extend lifespan in C. elegans. The n-butanol extracts in the root part showed best efficacy among them.ConclusionThe results show the n-butanol and aqueous extracts are the major pharmacological plant extracts. Moreover, the neuroprotective and lifespan-extension activity effects of root extracts are superior to leave extracts, supporting the traditional application of above-ground parts of DOH in treating various diseases associated with brain disorders and anti-aging. |
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| Keywords: | AD, Alzheimer's disease AR, roots parts were extracted by water AL, leaves parts were extracted by water BR, roots parts were extracted by n-butanol BL, leaves parts were extracted by n-butanol C. elegans, Caenorhabditis elegans CL, leaves parts were extracted by acetoacetate CR, roots parts were extracted by acetoacetate DOH, Damnacanthus officinarum Huang DMSO, dimethyl sulfoxide ER, roots parts were extracted by ethanol EL, leaves parts were extracted by ethanol E. coli, Escherichia coli FUDR, 5-fluorodeoxy-uridine GFP, green fluorescent protein HD, Huntington's disease M. officinalis, Morinda officinalis NGM, Nematode Growth Medium OD, optical density PD, parkinsonism dementia PL, leaves parts were extracted by petroleum PR, roots parts were extracted by petroleum polyQ, polyglutamine 5-HT, 5-hydroxytryptamine |
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