Cyclosporine stimulates hepatocyte proliferation and accelerates development of hepatocellular carcinomas in rats |
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| Authors: | Masuhara, Masaaki Ogasawara, Hisataka Katyal, Sikandar L. Nakamura, Toshikazu Shinozuka, Hisashi |
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| Affiliation: | Department of Pathology, University of Pittsburgh School of Medicine Pittsburgh, PA 15261, USA
1Department of Biology, Faculty of Science, Kyushu University Fukuoka 812, Japan |
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| Abstract: | A recent study from our laboratory demonstrated that cyclo-sporine(CsA), a prototype immunosuppressant, enhanced the growth ofcarcinogen-induced enzyme altered foci in rat liver, suggestingthat CsA may stimulate development of hepato-cellular carcinomas.In the present study, we examined (i) whether CsA acceleratesdevelopment of hepatocellular carcinomas in experimental animals,(ii) whether CsA stimulates the proliferation of resting hepatocytein vivo and (iii) whether CsA modulates the production of growthfactors implicated in liver cell growth, hepatocyte growth factor(HGF), transforming growth factor a (TGF |
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